Definition and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD)
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Treatment
There is no effective treatment to date in cases where MASLD has progressed into liver cirrhosis
Definition and treatment of metabolic dysfunction-associated steatohepatitis (MASH)
- Causes liver damage because a lot of fat is accumulated in the liver even when though alcohol has been hardly drunk
- Shows continuous elevation of hepatic enzyme values, and is common to the extent that enough that most cases where there is no history of alcohol intake and hepatitis B and hepatitis C have been serologically excluded correspond to MASH.
- Women account for 75% of the patients, the patients are obese, and 1/3 of the patients are diabetic
- Up to 30% of MASH progresses into hepatocirrhosis within 10 years
The treatment mechanisms of SUNIPla®-M such as antifibrosis, glucose/lipid metabolism control, and antioxidant activity, were confirmed in preclinical animal models of metabolic hepatocirrhosis.
| Project | Indication | Status | Discovery | Preclinical | GLP-Tox | Pre-IND | Clinical Trials (P1/P2/P3) |
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Project
SUNIPla®-M
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Indication Metabolic dysfunction-associated steatohepatitis |
Status preclinical |
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